Since 2022 saw an explosion of new competition in the sequencing market, I thought this would be a good time to review the market share breakdown for the various players. This should serve as a good reference point going forward to see what kind of impact all the new players will make. Rather than relying...
Most sequencing platform companies made their big announcements ahead of AGBT, including MGI. However, MGI hinted that there would be more to come in 2023, and it turns out AGBT is recapturing at least a little bit of its former glory of being THE place to make a big announcement. MGI, under the marketing efforts...
It has been a predictably pedestrian JP Morgan Healthcare Conference for the genomics market. Illumina, PacBio, and Ultima Genomics all made big announcements earlier this year. As such, JPM is more of a “status update” for them. The two non-stealth candidates for juicy updates are Singular Genomics and Element Biosciences. On Monday Singular came out...
With the JP Morgan update season about to get in full swing, I thought it might be a good time to review the sequencing field and where we stand at the beginning of 2023. The big news was, of course, that after years of having a virtual monopoly, Illumina faces a bevy of new competitors....
The sequencing market continued its “Big Announcement Season” at ASHG and this time it’s PacBio’s turn. Not to be outdone by Illumina’s NovaSeq X announcement, they introduced TWO major sequencing platforms - one for long reads and one for short reads. Long Reads Their new long read platform announcement came with a good level of...
The new sequencer we’ve been waiting for Chemistry X (er, XLEAP-SBS) is coming to the NovaSeq! 2.5 times more data (50B clusters, 2x150b reads)! Faster cycle times! Higher accuracy (I’ve seen both 2X and 3X). And a brand new running cost as low as $2/Gb. Yay! But it’s going to cost you $1.25M to get...
Single cell genomics completes the triumvirate of hot trends in genomics (the other two being liquid biopsies and spatial genomics). All three are driving a tremendous amount of demand for sequencing. There is a fairly broad range of companies that consider themselves to be “single cell”. Some focus solely on isolation of single (often rare)...
Back when Illumina first announced they were going to acquire GRAIL, the general feeling in the M&A field was that this wouldn’t trigger any antitrust issues. I was asked if I could think of any difficulties. I didn’t claim back then that I was an antitrust expert (and still don’t), but I did wonder if...
After a number of good suggestions, my list of spatial genomics platforms has grown to 18 (with four in the necropolis, mostly due to 10X Genomics acquisitions). [Edit: the list has now grown to 21 platforms.] There were a number of additional spatial protein platform suggestions, but many of these “high multiplexing” systems topped...
One of the hottest trends in NGS applications is that of spatial genomics - measuring nucleic acids and proteins while maintaining the XY (and sometimes Z) coordinates within the tissue sample. This is a very dynamic market with a variety of approaches with a lot of variability in terms of resolution, sampling method (explained below),...